Clinical features of calcineurin inhibitor-induced pain syndrome after allo-SCT

Abstract

Calcineurin inhibitor-induced pain syndrome (CIPS) is a rare but severe side effect of calcineurin inhibitors (CIs), such as CsA and tacrolimus (FK). This syndrome is characterized by severe, disabling, bilateral leg pain and preceding intolerable dermal pruritus without a skin rash. Bone scintigraphy shows increased joint and bone uptake, accentuated at the tarsus.1 This syndrome was initially recognized in the setting of organ transplantation1 and then also reported in patients following hematopoietic SCT (HSCT).2, 3, 4, 5 However, the clinical aspects of CIPS in HSCT remain unclear. Thus, records of patients who developed CIPS after HSCT in our hospital were retrospectively reviewed.