Clinical features and surgical treatment outcomes of Moyamoya disease in Jiangxi, China

Abstract

Objective To describe the clinical features and surgical treatment outcomes of patients with moyamoya disease (MMD) in Jiangxi Province of China. Methods Clinical features of a total of 1223 patients with MMD accepted treatment in our hospital from January 2005 to December 2015 were retrospectively analyzed. Totally, 228 patients with MMD accepted revascularization from November 2011 to November 2015; the surgical treatment outcomes were retrospectively analyzed. Results The ratio of male to female was 1:1.1 (580/643). The mean age was 45.1±12.2 years (ranged 3-79 years). Two definite peaks in age distribution were found (aged 4-10 and aged 38-51). High incidence was noted in Nanchang, Fuzhou, Yichun, and Shangrao. Ischemic symptoms appeared in children and intracranial hemorrhage appeared in adults; the majority of ischemic patients presented with transient ischemic attack, and in patients with hemorrhagic MMD, intraventricular hemorrhage was the most common type. Familial history was observed in only one patient. Totally 16 indirect and 232 combined revascularizations were performed in 248 hemispheres of 49 patients with hemorrlogic type MMD and 179 patients with ischemic type MMD. Perioperative complication was noted in 18 patients (7.9%). Follow-up showed that most patients had good prognosis. Conclusions There is no difference in the gender distribution of patients with MMD in Jiangxi province. Though two definite peaks in age distribution are found, the number of adult patients is larger than that of children, and primarily experiencing intracranial hemorrhage. There are few familial histories and regional concentration distribution. Individualized treatment with extra-intracranial revascularization is an effective treatment strategy for MMD. Key words: Moyamoya disease; Jiangxi; Clinical feature; Revascularization; Epidemiology