Clinical features and risk factors of patients in chronic kidney disease 4-5 phase complicated with pulmonary hypertension

Abstract

Objective To analysis the clinical features and risk factors of in chronic kidney disease (CKD)4-5 phase complicated with pulmonary hypertension(PH). Methods The consecutive patients who were diagnosed as CKD 4-5 phase wene enrolled between January 1, 2015 and December 31, 2015 in the Nephrology Department at the Central Hospital of Jiangmen. According to level of pulmonary arterial pressure, the patients were divided into the PH-group and the non-PH-group.The clinical and laboratory examinations of the patients were compared. Results The level of hemoglobin(Hb) was lower (P=0.008) and the serum parathyroid hormone was higher(P=0.013) in the PH-group.The dimensions of left atrium, right atrium, left ventricle and right ventricle were longer in the PH-group.The ejection fraction was lower in the PH-group(P=0.042). The probability of calcification of valves(56.43% vs 33.33%, P=0.001) and hydropericardium(42.85% vs. 28.21%, P=0.032) was higer in the PH-group. In the sub-group in hemodialysis patients, average time of dialysis was fewer in the PH-group(P=0.00), the Hb was lower and the serum creatinine and BUN levels were higher in the PH-group.In the sub-group in the peritoneal dialysis, average age of PH-group was higher((53.49±11.59) years old vs (46.19±12.82) years old, P=0.033). Anemia and hyperparathyroidism were the risk factors of CKD complicated with PH.Anemia and higher serum creatinine were the risk factors of hemodialysis complicated with PH.Old age was the risk factor of peritoneal dialysis complicated with PH. Conclusions The construction of heart in CKD patients changes and systole function was weaken with the PH develop.To control the anemia and hyperparathyroidism and to ensure the sufficiency of dialysis are the important measures to treat CKD complicated with PH. Key words: Chronic kidney disease; Pulmonary hypertension