Clinical features and risk factors for irritable bowel syndrome in Migraine patients.

Chunlin Li,Lei Zhang,Wenjing Tang,Jieqiong Liu,Jin Zhou,Huiying Li,Shengyuan Yu

doi:10.12669/pjms.333.12379

Abstract

Objective:Clinical and basic research increasingly suggests a correlation between migraine and irritable bowel syndrome (IBS). In this study, we aimed to explore the clinical features and risk factors for IBS in migraine patients.Methods:This was a retrospective, cross-sectional study. A total of 1,112 consecutive patients from the internal medicine and emergency departments of three hospitals from June 2014 through 2016. A comprehensive interviewer-administered questionnaire was designed based on the International Classification of Headache Disorders, 3rd edition (beta version).Results:The response rate was 94.6%. Among 1,052 participants, 287 suffered from migraine (27.3%) and 312 suffered from IBS (29.7%). A total of 79 patients suffered from both migraine and IBS (comorbidity rate: 7.5%). The migraine cohort exhibited a higher frequency of IBS than did the comparison cohort at baseline (P<0.05). Migraine patients with higher headache frequency, longer length of headache history, and anxiety disorders were more likely to also suffer from IBS (P=0.015). There were no significant differences between the two groups in age, sex, family history, duration of headache attack, migraine aura, headache intensity, or depression disorders (P>0.05). Multiple regression analysis indicated length of headache history and headache frequency were associated with IBS.Conclusion:Migraine patients with a long headache history, recurrent episodic headache attacks, and anxiety were more likely to have IBS.

Highlights

Migraine and irritable bowel syndrome (IBS) are both functional disorders characterized by recurrent pain in the absence of detectable causes for symptoms
This study aimed to explore the intrinsic link between IBS and migraine and reveal the clinical features of migraine patients with IBS
Among 1,052 participants, 287 suffered from migraine (27.3%) and 312 suffered from IBS (29.7%); 79 patients suffered from both migraine and IBS

Summary

Introduction

Migraine and irritable bowel syndrome (IBS) are both functional disorders characterized by recurrent pain in the absence of detectable causes for symptoms. IBS is more common in young and middle-aged people under the age of 50 years and more predominant in women.[1] The diagnosis of IBS is most frequently established by satisfying the symptom-based Rome 3 criteria, which include symptoms such as constipation/diarrhea, distention, abdominal pain and discomfort; in addition, organic gastrointestinal disease must be excluded. The etiologies and pathogenesis of IBS are not clear. The pathogenesis is primarily focused on the brain-gut axis, brain gut peptides, altered gut motility, immune system, visceral hypersensitivity, etc.[2]

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Conclusion