Abstract
Renal cancer morbidity grows in most of the developed countries. Incidence of bilateral renal cell carcinoma, per various authors, amounts to 2–6 % of all cases of this disease. The study included 160 patients with bilateral kidney cancer who received surgical treatment at the N.N. Blokhin National Medical Research Center of Oncology in the period from 1996 to 2014. Median follow-up duration for all patients included in the analysis was 81.05 ± 46.7 months. In our study, the groups for synchronous and metachronous cancer were equal (n = 80) and constituted 3.5 % of all cases of kidney cancer. For synchronous and metachronous cancer types, the most common concomitant disease was arterial hypertension. The most common morphological variant for the first, as well as the second, kidney tumor was clear cell carcinoma. Smoking and ischemic heart disease as a concomitant pathology negatively affected relapse-free and overall survival. Overall 5-year survival for synchronous renal cancer was 84.4 ± 4.2 %, for metachronous – 64.8 ± 9.3 %.
Highlights
Clinical features and results of surgical treatment of bilateral renal cancer M.I
Median follow-up duration for all patients included in the analysis was 81.05 ± 46.7 months
Relapse-free survival of patients with bilateral renal cell carcinoma depending on surgical treatment of cancer of the first kidney
Summary
При сравнении характеристик больных двусторонним раком почек показано, что средний возраст выявления первого рака почки в группе больных с метахронным вариантом развития опухолей был значимо меньше и составил 50,6 года, в то время как при синхронном варианте рак первой почки диа гностировали в возрасте 55,3 года Пациентов с МРП в возрасте старше 65 лет на момент выявления рака первой почки было значимо меньше по сравнению с больными СРП (3,8 % (n = 3) и 16,3 % (n = 13) соответственно). Принимая во внимание тот факт, что 73 (91,2 %) больным МРП и 9 (11,2 %) больным СРП хирургическое вмешательство по поводу рака первой почки было проведено в других лечебных учреждениях, анализируемые группы пациентов значимо различались по частоте выполнения нефрэктомий и органосохраняющих операций. Comparative characteristics of patients with metachronous and synchronous bilateral renal cell carcinoma
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