Clinical features and prognostic factor analysis of gliosarcomas

Abstract

Objective To discuss the clinical characteristics and prognostic factors of gliosarcomas. Methods A total of 188 patients with primary gliosarcomas who underwent surgical treatment from January 2008 to January 2018 at Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University were retrospectively analyzed.The incidence of gliosarcoma among the gliosarcoma and glioblastoma was 5.15% (188/3 647). The clinical features were summarized and influencing factors of outcomes including progression-free survival (PFS), overall survival (OS) and tumor recurrence and metastasis were investigated.Univariate Log-rank analysis and multivariate Cox regression analysis were used to analyze the factors. Results Among the 188 patients, gross total resection was achieved in 143 patients, sub-total resection in 37 and partial resection in 8. After surgery, 169 patients received radiotherapy and chemotherapy, 13 received radiotherapy only and 6 did not undergo radiotherapy or chemotherapy. The median follow-up period was 15 months (range: 3-28 months). The median OS was 15 months(range: 4-28 months), and the median PFS was 8 months(range: 3-18 months). Log-rank univariate analysis showed that age, extent of tumor resection and postoperative radiotherapy and chemotherapy were influencing factors for OS and PFS (all P 0.05). Univariate and multivariate Cox regression analysis showed that age, extent of tumor resection and postoperative radiotherapy and chemotherapy affected the OS and PFS of the patients (all P<0.05). Conclusions Gliosarcoma is rare and its prognosis seems poor. The age < 60 and maximum tumor resection combined with postoperative adjuvant radiotherapy and chemotherapy could prolong the survival of patients. Key words: Gliosarcoma; Clinical features; Prognosis; Root cause analysis