Clinical features and prognostic analysis of 66 patients with pharyngeal lymphatic ring diffuse large B-cell lymphoma

Abstract

Objective To analyze the clinical features, prognosis and its influence factors of pharyngeal lymphatic ring diffuse large B-cell lymphoma. Methods 66 cases diagnosed with pharyngeal lymphatic ring diffuse large B-cell lymphoma were analyzed retrospectively, including 13 nasopharynx cases, 49 tonsil cases and 4 tongue root cases. The patients in Ⅰ-Ⅱ phases were mainly treated with chemotherapy plus involvement wild illuminate, and the patients in Ⅲ-Ⅳ phases were mainly treated with chemotherapy. Results Most patients with pharyngeal lymphatic ring diffuse large B-cell lymphoma were in phase Ⅱ, showing that neighboring organs were infiltrated, but rare systemic symptom, spleen were invaded and lactic acid dehydrogenase was increased. The overall survival rates of 3 and 5 years in patients with pharyngeal lymphatic ring diffuse large B-cell lymphoma were 77.9 % and 66.9 % respectively. The single-factor analysis indicated that the lactic acid dehydrogenase ≥ 248 U/L, the international prognostic index (IPI) score ≥1, and ECOG score ≥2 were the adverse prognosis influence factors. The multiple-factor analysis showed that the IPI score ≥ 1 was related to poor prognosis of pharyngeal lymphatic ring diffuse large B-cell lymphoma. Conclusion Pharyngeal lymphatic ring diffuse large B-cell lymphoma has unique clinical characteristics, and IPI score can influence the prognosis. Key words: Pharyngeal lymphatic ring; Lymphoma, large B-cell, diffuse