Clinical features and prognosis analysis of 15 cases of extra-nodal nasal-type natural killer/T-cell lymphoma originated from the larynx

Abstract

Objective To analyze the clinical features and prognosis of extra-nodal nasal NK/T cell lymphoma originated from the larynx. Methods Clinical data of 15 cases of extra-nodal nasal NK/T-cell lymphoma originated from the larynx were retrospectively analyzed. The overall survival (OS) and progression-free survival (PFS) were calculated by Kaplan-Meier survival analysis. The effect of different clinical factors on the clinical prognosis was assessed by univariate analysis. Results Among 15 patients, 13 cases were male and 2 female. The median age of onset was 40 years. In 8 cases, the lesions were confined to the larynx, and only 4 cases suffered from cervical lymph node involvement. According to Ann Abor staging, 11 cases were classified as grade I, 3 as grade Ⅱ and 1 as grade Ⅲ.The median OS was 28.0 months and the 5-year OS was 32.0%.The median PFS was 24.7 months and the 5-year PFS was 33.3%.Among 14 patients with stage Ⅰ/Ⅱ, the clinical prognosis of patients receiving combined chemo-radiotherapy was significantly better than those of their counterparts undergoing radiotherapy or chemotherapy alone (median OS: 37.2 vs.11.2 vs.3.7 months, P=0.004). Conclusion Extra-nodal nasal NK/T cell lymphoma originated from the larynx is extremely rare, predominantly in middle-aged male patients. The general condition is relatively favorable. Patients present with multiple lesions in the early stage and relatively poor prognosis. The clinical efficacy of chemotherapy combined with radiotherapy is probably higher compared with that of radiotherapy or chemotherapy alone. Key words: Extra-nodal natural killer/T-cell lymphoma, nasal type; Larynx; Prognosis