Abstract
Transplacental transmission of Zika virus has been reported during all trimesters of pregnancy and might lead to central nervous system anomalies, including microcephaly. We report 3 cases of perinatal Zika infection identified during the epidemic in Colombia and provide detailed descriptions of clinical features, diagnosis, and neurodevelopmental outcome at 18 months of age (corrected).
Highlights
Transplacental transmission of Zika virus has been reported during all trimesters of pregnancy and might lead to central nervous system anomalies, including microcephaly
The emergence of Zika virus (ZIKV) in the Americas has coincided with an abnormal increase in prenatal and neonatal documented cases of microcephaly and other anomalies of the central nervous system [1] These alterations of the brain, along with animal models of vertical transmission of ZIKV, a single-stranded RNA flavivirus, are evidence of the neurotropic nature of the virus [2,3,4]
Vertical transmission and infection of the fetus during all 3 trimesters of pregnancy with ZIKV has been extensively reported, but little is known about perinatal transmission; only a few cases have been reported [5,6,7,8]
Summary
Transplacental transmission of Zika virus has been reported during all trimesters of pregnancy and might lead to central nervous system anomalies, including microcephaly. We report 3 cases of perinatal ZIKV infection during the epidemic of Zika in Colombia and data on the neurodevelopmental outcome at 18 months of age (corrected). Case-patient 1 was a 26-year-old pregnant woman in labor who was admitted to the Hospital Universitario de Santander on August 7, 2015, after she reported fever, exanthema (maculopapular rash on the torso), and osteoid–muscular pains (Figure).
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