Abstract
The aim of the present study was to describe and analyze data of 57 women with borderline ovarian tumors (BOTs) regarding histological characteristics, clinical features and treatment management at the Department of Obstetrics and Gynecology of the Universidade Estadual de Campinas (Unicamp, in the Portuguese acronym). The present retrospective study analyzed data obtained from clinical and histopathological reports of women with BOTs treated in a single cancer center between 2010 and 2018. A total of 57 women were included, with a mean age of 48.42 years old (15.43-80.77), of which 30 (52.63%) were postmenopausal, and 18 (31.58%) were < 40 years old. All of the women underwent surgery. A total of 37 women (64.91%) were submitted to complete surgical staging for BOT, and none (0/57) were submitted to pelvic or paraortic lymphadenectomy. Chemotherapy was administered for two patients who recurred. The final histological diagnoses were: serous in 20 (35.09%) cases, mucinous in 26 (45.61%), seromucinous in 10 (17.54%), and endometrioid in 1 (1.75%) case. Intraoperative analyses of frozen sections were obtained in 42 (73.68%) women, of which 28 (66.67%) matched with the final diagnosis. The mean follow-up was of 42.79 months (range: 2.03-104.87 months). Regarding the current status of the women, 45 (78.95%) are alive without disease, 2 (3.51%) are alive with disease, 9 (15.79%) had their last follow-up visit > 1 year before the performance of the present study but are alive, and 1 patient (1.75%) died of another cause. Women in the present study were treated according to the current guidelines and only two patients recurred.
Highlights
Borderline ovarian tumor (BOT) is a peculiar type of tumor with an indolent behavior
Women in the present study were treated according to the current guidelines and only two patients recurred
The objective of the present study was to describe and analyze the clinical features, the tumor histology, and the treatment of women with BOT in a single cancer center, in Campinas, state of São Paulo, Brazil, between the years 2010 and 2018. This is a retrospective study, which evaluated women included from the period of January 2010 to April 2018 at the Centro de Atenção Integral à Saúde da Mulher (CAISM, in the Portuguese acronym) of the Universidade Estadual de Campinas (Unicamp, in the Portuguese acronym), a tertiary cancer center specialized in gynecological malignancies
Summary
Borderline ovarian tumor (BOT) is a peculiar type of tumor with an indolent behavior. This disease occurs in women 10 years younger than those with epithelial ovarian cancer (EOC). They are more frequently diagnosed in the earlier stages (75% in stage I), leading to an excellent prognosis. Surgery is indicated for women with suspicious adnexal masses detected in ultrasound (US) or in other preoperative exams. The preoperative differential diagnosis is important, allowing adequate surgery planning; performances of imaging and biomarkers may fail to discriminate EOC in the initial stages from BOT cases.[3,4] Besides, frozen-section readings will never achieve 100% of accuracy; despite the possibility of underdiagnosis and overdiagnosis, they may provide guidance in most cases.[2,5,6]
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