Clinical Features and Laboratory Examination Results of Sjogren's Syndrome Complicated with Thyroid Disorders: A Retrospective Analysis.

Min Dai,Qian Huang,Jing Wang,Le Sun

doi:10.1155/2021/2280070

Min Dai, Qian Huang + Show 2 more

Open Access

https://doi.org/10.1155/2021/2280070

Copy DOI

Abstract

Objective To analyze the clinical incidence, clinical manifestations, laboratory examination, and complications of Sjogren's syndrome complicated with thyroid disorders in patients and to explore the clinical significance of its occurrence and concurrence relationship. Methods The clinical manifestations, thyroid function, antithyroid antibodies, immunology indicators, autoantibodies, and routine laboratory examination items of 201 patients with Sjogren's syndrome in Chongqing Hospital of Traditional Chinese Medicine were reviewed and analyzed. According to whether the thyroid function was abnormal or not, the patients were divided into the group of Sjogren's syndrome complicated with abnormal thyroid function (n = 36) and the group of Sjogren's syndrome without abnormal thyroid function (n = 165). The clinical symptoms and test indicators of the two groups were compared. Results Among 201 patients with Sjogren's syndrome, 36 patients had abnormal thyroid function (17.9%) and 36 patients with abnormal thyroid function had hypothyroidism. The abnormal renal function, decreased Hb, decreased WBC, increased ESR, and decreased C4 were more significant in the group with Sjogren's syndrome complicated with abnormal thyroid function, which had significant differences compared with the group with normal thyroid function (P < 0.05). The positive rates of aTG and aTPO in patients with Sjogren's syndrome complicated with thyroid disorders were higher than that in the normal group, and the difference between the two groups was statistically significant (P < 0.05). Conclusion Patients with Sjogren's syndrome are often associated with hypothyroidism, and these patients may have more severe immune disorders, anemia, leukopenia, and renal involvement. The results show that paying attention to the detection of thyroid function in patients with Sjogren's syndrome may be of positive significance to judge the condition and prognosis.

Highlights

Sjogren’s syndrome is a systemic chronic autoimmune disease mainly affected by exocrine glands such as the tear glands and salivary glands
Autoimmune thyroid disease is a common organ-specific autoimmune disease, including Graves’ disease, autoimmune thyroiditis/Hashimoto’s disease, and primary hypothyroidism. e thyroid gland, salivary gland, and lacrimal gland are vulnerable to immune injury
Among 201 patients with Sjogren’s syndrome, 36 cases (17.9%) had abnormal thyroid function, and 165 cases (81.9%) had normal thyroid function. 36 patients with abnormal thyroid function were classified as an abnormal group

Summary

Introduction

Sjogren’s syndrome is a systemic chronic autoimmune disease mainly affected by exocrine glands such as the tear glands and salivary glands. Primary Sjogren’s syndrome refers to connective tissue disease diagnosed without another diagnosis, and secondary Sjogren’s syndrome refers to the disease associated with another clearly diagnosed connective tissue disease (such as systemic lupus erythematosus and rheumatoid arthritis). Thyroiditis is a specific autoimmune disease involving a single organ. Sjogren’s syndrome is a systemic autoimmune disease involving the salivary gland and lacrimal gland, and the two often coexist in clinical practice. Sjogren’s syndrome can affect multiple organs in addition to the involvement of Journal of Healthcare Engineering exocrine glands, among which thyroid involvement is more common.

Methods

Results

Discussion

Conclusion