Clinical Features and Early Effect in EVI1 Positive Acute Myeloid Lleukemia

Abstract

Objective To investigate the clinical biological characteristics of EVI1 positive acute myeloid leukemia (AML) and its effect on early chemotherapy. Methods The clinical and biological characteristics of 33 AML patients with EVI1 positive were retrospectively analyzed in 361 AML patients who were diagnosed and treated in our institute from March 2015 to July 2016, and the clinical and biological features, rate of the induced remission were compared between intermediate risk and poor risk with EVI1 positive AML, moreover, the influential factors on complete remission(CR) were analyzed. The expression of EVI1/ABL was tested in 32 healthy donors to confirm the abnormal threshold of EVI1 expression. Results The definition of EVI1 positive was that the quantitative expression of EVI1/ABL was more than 8.0%. 33 AML patients with EVI1 positive were found in 361 newly diagnosed AML patients, in which the female and male patients were 17and 16 respectively, the median age was 45(18-67), with a median follow-up of 6.6(0.7-13.2) months. Intermediate karyotype was found in 17 patients(including 9 patients with normal karyotypes,1 patient with +8); unfavorable karyotype was found in 14 patients(including 7 patients with -7/7q-,4 patients with t(v;11q23), 3 patients with inv(3)/t(3;3), 2 patients without mitotic figures).The rate of CR in the first induction chemotherapy was 42.4%, and the rate of total CR was 60.6%. According to the NCCN, 16 intermediate risk patients and poor risk patients were devided, without favorable risk patients. The rate of CR in first induction chemotherapy were 68.8% and 17.6%(P=0.005) in the intermediate risk and poor risk respectively, that of total CR were 81.3% and 41.2%(P=0.032),and the rate of relapse were 7.7% and 14.3%. Univariable analysis revealed that unfavorable karyotype could affect the rate of CR in the first reduction chemotherapy and that of total CR(P=0.004、0.029).Neither the rate of CR in first induction chemotherapy nor that of total CR was affected by the age, karyocyte, the expression level of EVI1 at diagnosis through multivariate analysis. The poor risk patients had higher mortality (41.2% VS 6.3%, P=0.039) and lower overall survival(OS)(P=0.012). Conclusions EVI1 may not be an independent prognostic factor for the AML patients considering the appearance in the intermediate and poor risk patients. It predicts poor outcome in the EVI1 positive AML patients who has unfavorable karyocyte such as -7/7q-,t(v;11q23),and inv(3)/t(3;3),and also low rate of both CR in first induction chemotherapy and total CR. It also has a low rate of long-term survival and high mortality in the AML patients with EVI1 positive, who may benefit from allogeneic bone marrow transplantation as soon as possible. DisclosuresNo relevant conflicts of interest to declare.