Abstract
BackgroundCoronavirus disease 2019 (COVID-19) has spread around the world. This retrospective study aims to analyze the clinical features of COVID-19 patients with cancer and identify death outcome related risk factors.MethodsFrom February 10th to April 15th, 2020, 103 COVID-19 patients with cancer were enrolled. Difference analyses were performed between severe and non-severe patients. A propensity score matching (PSM) analysis was performed, including 103 COVID-19 patients with cancer and 206 matched non-cancer COVID-19 patients. Next, we identified death related risk factors and developed a nomogram for predicting the probability.ResultsIn 103 COVID-19 patients with cancer, the main cancer categories were breast cancer, lung cancer and bladder cancer. Compared to non-severe patients, severe patients had a higher median age, and a higher proportion of smokers, diabetes, heart disease and dyspnea. In addition, most of the laboratory results between two groups were significantly different. PSM analysis found that the proportion of dyspnea was much higher in COVID-19 patients with cancer. The severity incidence in two groups were similar, while a much higher mortality was found in COVID-19 patients with cancer compared to that in COVID-19 patients without cancer (11.7% vs. 4.4%, P = 0.028). Furthermore, we found that neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) were related to death outcome. And a nomogram based on the factors was developed.ConclusionIn COVID-19 patients with cancer, the clinical features and laboratory results between severe group and non-severe group were significantly different. NLR and CRP were the risk factors that could predict death outcome.
Highlights
Coronavirus disease 2019 (COVID-19) has spread around the world
Renal function and biochemical indexes between severe and non-severe patients with cancer, we found that lactate dehydrogenase (LDH), alpha-hydroxybutyric dehydrogenase, D-dimer, N-terminal pro brain natriuretic peptide (NTproBNP), aspartate transaminase (AST) and Uric acid were higher while total protein, albumin and albumin/globulin were lower in the severe group (Table 2)
We found that white blood cell (WBC) count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) were higher in non-survivors, while lymphocyte count was lower in non-survivors
Summary
Coronavirus disease 2019 (COVID-19) has spread around the world This retrospective study aims to analyze the clinical features of COVID-19 patients with cancer and identify death outcome related risk factors. People with diabetes [3], hypertension [4], and heart disease [5] were thought to be susceptible to COVID-19 and had poor clinical outcome. Cancer patients were considered to have lower immunity than normal people. They were susceptible to infected with bacteria and viruses [6, 7]. Immunosuppression status of cancer patients put them at an increased risk of COVID-19
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