Clinical features analysis in lung adenocarcinoma patients complicated with pulmonary thromboembolism

Abstract

Objective To analyze the clinical characteristics of lung adenocarcinoma complicated with pulmonary thromboembolism in order to improve the clinical management. Methods A 1∶1 matched and retrospective study was conducted.41 patients with lung adenocarcinoma complicated with pulmonary thromboembolism admitted to the First Affiliated Hospital of Guangzhou Medical University/Guangzhou Institute of Respiratory Disease from June 2013 to March 2016 were identified as study group.Another 41 patients with simple lung adenocarcinoma matched sex, age (±four years old), therapy and baseline diseases with study group in the same study period were selected as control group.Univariate analysis and logistic analysis were used to identify the risk factors of pulmonary thromboembolism. Results There was no significant difference between two groups in the incidences of the primary clinical symptoms including cough, dyspnea, chest pain and hemoptysis.Compared with the control group, incidence of swelling and pain in lower limbs was higher in the study group (χ2=6.474, P<0.05), the proportion of patients in stage Ⅲ and Ⅳ was significantly higher in the study group (χ2=8.002, P<0.05). The white blood cell count, D-dimer, neuron specific enolase, carcinoembryonic antigen, carbohydrate antigen 125, and carbohydrate antigen 15-3 and L858R EGFR mutation rate in the study group were statistically higher than those in the control group (all P<0.05). Logistic regression analysis revealed that only D-dimer and L858R EGFR mutation were risk factors for pulmonary embolism in lung adenocarcinoma. Conclusions D-dimer and L858R EGFR mutation are the risk factors for pulmonary embolism in lung adenocarcinoma. Key words: Lung adenocarcinoma; Venous thromboembolism; D-dimer; Tumor stage; Tumor marker; Epidermal growth factor receptor mutation