Clinical Factors Associated with Asymptomatic Women Having Inconclusive Screening Mammography Results: Experiences from a Single Medical Center in Taiwan.

Chun-Li Wang,Shun-Fa Yang,Chia-Yen Lin,Pi-Shan Hsu

doi:10.3390/ijerph18105410

Abstract

Screening mammography is used worldwide for the early detection of breast cancer in women experiencing no symptoms. The Breast Imaging Reporting and Database System (BI-RADS) is used to report mammographic findings. However, little is known about the clinical characteristics of Asian women with BI-RADS category 0, and we aimed to explore such characteristics in the context of Taiwan. This retrospective cross-sectional study was conducted using data from a single tertiary medical center. We examined the association of blood test data and estrogen exposure–related medical histories with BI-RADS reports from screening mammography of 4280 women between 1 January 2010 and 31 July 2019. The data of 4280 participants were evaluated, and they were categorized into BI-RADS category 0 (n = 413; 9.6%) and 1–5 (n = 3867; 90.4%) subgroups. In a multivariate analysis, breast surgery history and premenopausal status had a positive relationship with a category 0 status, with respective risk increases of 64% and 34% (p = 0.010 and 0.013). Hormone contraceptive use for ≥5 years was a negative independent predictor of having a category 0 status. In conclusion, breast surgery history and premenopausal status significantly increased the likelihood of individuals having incomplete mammographic findings, even when they were older than 45 years. Identifying related factors before screening mammography is helpful for clinical physicians to arrange more proper and alternative examination and obtain a definite diagnosis.

Highlights

Breast cancer is the third leading cause of cancer death among women in Taiwan.In 2017, approximately 13,965 women were diagnosed as having the disease, and more than 2300 women died of it
Radiologists assess the mammography findings according to the American
This study investigated the association between factors, including patients’ clinical characteristics and metabolic abnormalities, especially metabolic syndrome components, and women having incomplete screening mammography examinations in Taiwan

Summary

Introduction

Breast cancer is the third leading cause of cancer death among women in Taiwan. In 2017, approximately 13,965 women were diagnosed as having the disease, and more than 2300 women died of it. The rate of new cases of female breast cancer was 117.8 per. 100,000 women per year and the mortality rate was 20.1 per 100,000 women per year. The updated recommendations of the US Preventive Services Task Force in 2016 suggest biennial screening mammography for women aged 50 to 74 years (B Recommendation) [2]. In Taiwan, the Health Promotion Administration policy on cancer screening stipulates free mammography for breast cancer screening once every two years for women aged 45 to 69 years or those aged 40 to 44 years whose second-degree relatives have had breast cancer.

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