Abstract

Clinical Experience with the Hybrid Closed-Loop Insulin Delivery System (MinimedTM 670G) compared to Sensor Augmented Therapy (MiniMedTM 640G) and standard care

Highlights

  • This real-world clinical study compared the efficacy of a hybrid closed-loop system (HCL) to a sensor integrated pump (SIP) system and usual care

  • The reduction in percent time in severe hypoglycemia (

  • Less time was spent above 180 mg/dl (37% at baseline, 32.1% with SIP and 25.5% with HCL)

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Summary

Methods

Twenty-four subjects aged 8 to 65 years were randomly selected from 6 clinical centers to take part in this prospective study. Six Diabetes Centers with extensive experience in insulin pump therapy were identified. These included 4 Adult centers and 2 pediatric centers. Each center was asked to randomly select 4 type 1 subjects for the study. 24 subjects were enrolled into the study. Subjects were on a variety of therapies for their diabetes. Subjects were eligible for recruitment if they were 7 years of age or older, not pregnant, and using a minimum of 8 units of insulin per 24 hours. Subjects with any other systemic disease or any therapy other than insulin were excluded

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