Abstract
Cannabis has been widely used as a medicinal plant for millennia; however, studies related to its main components were first conducted in 1960. Subsequently, laboratories have produced new components and structures related to its active biological properties. Countries that have approved the medicinal use of cannabis impose regulations that govern its clinical and scientific use. One means of administering medicinal cannabis is via a magistral preparation that must have a medical prescription and be prepared in an establishment that meets quality standards to ensure the quantities of its main components, such as tetrahydrocannabinol (THC) and cannabidiol (CBD). Furthermore, suppliers must have a clear indication of its use in the patient before prescription. This review shows the published evidence regarding the clinical use of medicinal cannabis magistral preparations in the management of post-chemotherapy nausea and vomiting, neuropathic pain in multiple sclerosis, and anorexia and cachexia in patients with HIV.
Highlights
Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, Abstract: Cannabis has been widely used as a medicinal plant for millennia; studies related to its main components were first conducted in 1960
Due to the scarce evidence reported in the literature on the clinical use of cannabis-based magistral preparations, the objective of this review is to describe the pharmaceutical aspects and risk management focused on adverse events and interactions of the magistral preparations in three main applications: (i) management of nausea and vomiting post-chemotherapy, (ii) neuropathic pain in multiple sclerosis, and (iii) anorexia and cachexia in HIV
To increase consistency between the results, the three reviewers reviewed the 735 articles selected for the indication of anorexia and cachexia in HIV, 742 articles for the indication of post-chemotherapy nausea and vomiting, and 763 articles for the indication of neuropathic pain in multiple sclerosis
Summary
Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, Abstract: Cannabis has been widely used as a medicinal plant for millennia; studies related to its main components were first conducted in 1960. The Middle East, and Africa, where it was used for religious, social, and cultural purposes These included the manufacture of ropes and health treatments, for which it showed benefits for use in certain refractory diseases as an alternative to conventional management [1]. This situation changed with the stigmatization of use at the end of the 19th century, when the epidemic of opioid abuse arose and legislation was introduced that regulated chemical substances related to psychoactive components, mainly as a control measure to address addiction. In 1939, the Colombian government prohibited the cultivation of the plant and ordered the destruction of existing plantations [2]
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