Abstract
A clinical study was conducted to evaluate the efficacy of 2-aza-8-oxohypoxanthine (AOH) on human skin in a double-blind, placebo-controlled, and split-face comparative trial. To this end, a topical lotion containing 0.1% of AOH and its placebo formulation were applied in 20 Japanese subjects (age: 41–58 years, average: 48.4 ± 4.7 years) to their faces daily for eight weeks. The moisture content in the stratum corneum and the trans-epidermal water loss (TEWL) were measured at the beginning of the study and after eight weeks. The results obtained upon comparing the data of the two measuring points showed that the 0.1% AOH lotion caused a statistically significant larger decrease in TEWL after eight weeks. Moreover, the 0.1% AOH lotion produced a larger increase in the moisture content in the stratum corneum after eight weeks, although there was no statistical difference between the two formulations. These results clearly indicate that AOH is effective as a cosmetic agent with a skin barrier function against water loss.
Highlights
When one observes a lawn, one may notice a naturally occurring thicker ring compared to the surrounding turf grass
The cause of the phenomenon of the formation of fairy rings had long remained a mystery before our study in 2010; we discovered a substance that is involved in the formation of fairy rings—2-azahypoxanthin (AHX), a plant growth stimulant, in the mycelial culture broth of Lepista sordida, a kind of fairyring-forming mushroom
A comparison of the above data revealed that the stratum corneum water content showed an increasing trend for both the 0.1% AOH lotion and the placebo lotion
Summary
When one observes a lawn, one may notice a naturally occurring thicker ring compared to the surrounding turf grass. The cause of the phenomenon of the formation of fairy rings had long remained a mystery before our study in 2010; we discovered a substance that is involved in the formation of fairy rings—2-azahypoxanthin (AHX), a plant growth stimulant, in the mycelial culture broth of Lepista sordida, a kind of fairyring-forming mushroom. It was found that FCs increased the yield of crops such as rice and wheat [4,8,9]. These results suggest that FCs may be a new family of plant hormones [10,11]
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