Clinical evaluation of the wireless JSPH-2 esophageal pH capsule: a single-center retrospective experience

Abstract

Background/aim JSPH pH wireless capsule is a radio-telemetric capsule that attaches to the lower end of esophageal mucosa and measures pH and sends data to a wireless receiver. The aim of the study was to assess the clinical efficacy and safety of the JSPH pH wireless capsule in Kuwaiti patients with symptoms suggestive of gastroesophageal reflux disease (GERD).Patients and methods Patients with symptoms suggestive of GERD were included in the study. The JSPH-2 pH wireless capsule-recorded data were automatically analyzed by pH capsule data analyze software with pH tracings of day 1, day 2, and total 48-h test periods.Results A total of 63 patients from Jahra Hospital, Kuwait, were included in this study. A total of 43 (68.2%) patients had recorded parameters suggestive of GERD, whereas 20 (31.8%) patients were defined as non-GERD. On comparison of different recorded parameters suggestive of GERD between day 1 and day 2, the number of refluxes (P=0.048), total fraction time pH less than 4 (P=0.042), meal fraction time pH less than 4 (P=0.047), and DeMeester score (P=0.047) were statistically significant on day 1. On day 2, only five (11.6%) patients with GERD had been identified with abnormal pH data, whereas nine (20.9%) patients had been identified with an abnormal DeMeester score. A total of 14 (22.2%) patients reported mild to moderate disturbance of normal daily activities, diet, and sleeping during the monitoring period. A total of 32 (57.1%) patients experienced foreign body sensation, 15 (23.8%) showed chest discomfort, and seven (11.1%) had nausea.Conclusion The JSPH pH monitoring system is safe and well tolerated and can be used in clinical practice for diagnosis and monitoring of patients with GERD.