Abstract
The incidence of liver diseases is increasing globally, and many patients in developing countries are resorting to the use of herbal products as treatment. This study was aimed at establishing the safety and effectiveness outcomes for patients with deranged liver panel treated with a Ghanaian finished polyherbal product. The product Heptonica is prepared by CPMR from three medicinal plants: Bidens pilosa, Citrus aurantifolia, and Trema orientalis. Fifty (50) participants with clinical and biochemical signs of liver impairment were purposively recruited and treated for a period of 28 days. Participants received Heptonica at a dose of 30 mL 8 hourly after meals for the treatment period. Clinical and biochemical evaluation (liver panel test, renal function test, haematology, and urinalysis) of subjects for the safety and effectiveness of the product was undertaken at days 0 (baseline), 14, and 28. Compared to the baseline values, Heptonica did not have any untoward effect on renal function, haematological parameters, and urine parameters of subjects. Clinical and liver panel results of the participants also improved compared to the baseline: serum aspartate transaminase (AST) (p < 0.0001), alanine transaminase (ALT) (p < 0.0001), gamma-glutamyltransferase (GGT) (p- 0.0013), total bilirubin (p-0.0136), direct bilirubin (p < 0.0001), total proteins (p-0.0409), and alkaline phosphates (p- 0.0284). Level of albumin showed no significant difference within the study period. The outcome of this study indicates Heptonica has hepatorestorative action with no observable toxicity and can be used with confidence as indicated as a liver tonic.
Highlights
IntroductionCherniack e incidence of liver diseases is increasing globally, and many patients in developing countries are resorting to the use of herbal products as treatment
E incidence of liver diseases is increasing globally, and many patients in developing countries are resorting to the use of herbal products as treatment. is study was aimed at establishing the safety and effectiveness outcomes for patients with deranged liver panel treated with a Ghanaian finished polyherbal product. e product Heptonica is prepared by Centre for Plant Medicine Research (CPMR) from three medicinal plants: Bidens pilosa, Citrus aurantifolia, and Trema orientalis
Out of the 50 participants, 39 (78%) were males and the remaining 11 (22%) were females (Table 1). is observation is consistent with findings from other studies confirming gender differences in the prevalence of liver diseases [18]. e high rate of the deranged liver panel in males may be attributed to their risky lifestyle
Summary
Cherniack e incidence of liver diseases is increasing globally, and many patients in developing countries are resorting to the use of herbal products as treatment. Is study was aimed at establishing the safety and effectiveness outcomes for patients with deranged liver panel treated with a Ghanaian finished polyherbal product. Fifty (50) participants with clinical and biochemical signs of liver impairment were purposively recruited and treated for a period of 28 days. Clinical and biochemical evaluation (liver panel test, renal function test, haematology, and urinalysis) of subjects for the safety and effectiveness of the product was undertaken at days 0 (baseline), 14, and 28. Lack of affordable and accessible therapeutic agents for the treatment of liver diseases is impeding the quality of life of patients as well as increasing mortality [4]. Some of the few allopathic drugs for treating liver diseases are limited in efficacy and compounded by toxic side effects [11]
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