“CLINICAL EVALUATION OF THE EFFECT OF A NOVEL LACTOFERRIN CONTAINING TOOTHPASTE AS AN ADJUNCT TO SCALING AND ROOT PLANING IN IMPROVING PLAQUE CONTROL AND GINGIVAL HEALTHA RANDOMIZED CONTROLLED CLINICAL TRIAL”.

Abstract

Aims and objectives: To evaluate the effect of a DENTE91® (novel lactoferrin based toothpaste) in comparison to Standard fluoride based toothpaste as an adjunct to scaling and root Planing in improving plaque control and gingival health. This was an examiner-blinded, parallel group, randomized, controlled trial enrolled total 10 Methodology: 0 healthy subjects aged 18 to 35 years (both inclusive) who had dental biofilm induced gingivitis, with at least 20 natural teeth, who exhibited no evidence of clinical attachment loss and was ready to give written informed consent were enrolled. Mean ± SD plaque Index score with Turesky–Gilmore–Glickman modification of Quingley Hein Results: plaque index (S) was statistically significant within Test group (1.44 ± 0.40) and Control group (1.79 ± 0.36) as compared to baseline (2.48 ± 0.43 in Test group and 2.72 ± 0.33 in Control group). Mean % ± SD reduction in plaque index score at Week 4 was 42.04% ± 11.04% in Test group and 34.19% ± 14.21% in Control group as compared to baseline. Reduction in plaque index was comparable between Dente 91® (Test group) and Standard fluoride based toothpaste. Mean ± SD gingival Index score based on Loe and Silness, 1963 method was statistically significant at Week 4 (0.76 ± 0.38 in Test group and 1.34 ± 0.56 in Control group) when compared to baseline (22.70 ± 0.67 in Test group and 2.65 ± 0.52 in Control group). Mean % ± SD reduction in gingival Index score at Week 4 was 71.29% ± 12.96% in Test group and 48.54% ± 21.94% in Control group as compared to baseline. Reduction in Gingival Index score was statistical significant (p=0.001) in Dente 91® (Test group) compared to Standard fluoride based toothpaste (Control group). The main Conclusion: finding was that Test group who had used DENTE91® toothpaste containing lactoferrin had significantly better gingival health status than the Control group in terms of gingival inflammation and gingival bleeding. Significant reduction in plaque index score was comparable between Test group and Control group.