Abstract
Introduction In recent years, the field of glycobiology has emerged due to its relevant discoveries in biological as well as medical field with special reference to cancer.1 Glycans have gained importance due to its role in fundamental mechanisms of malignant transformation of the cells and vario
Highlights
In recent years, the field of glycobiology has emerged due to its relevant discoveries in biological as well as medical field with special reference to cancer. 1 Glycans have gained importance due to its role in fundamental mechanisms of malignant transformation of the cells and various cellular mechanisms that includes cell signaling, tumor cell invasion and metastasis and immune modulation. 2They are ubiquitously present in all biological systems on the cell surface as a complex array of sugar chains which are mainly conjugated to proteins and lipids
The mean concentrations of Total Sialic Acid (TSA) and Lipid Bound Sialic Acid (LBSA) were increased in oral cancer patients in comparison with controls as well as non-cancer tobacco chewers/ smokers
The difference between healthy controls and Head and Neck Squamous cell carcinoma (HNSCC) patients, HNSCC and non-cancer tobacco chewers/smokers and Healthy controls and non-cancer tobacco chewers/smokers were statistically significant by individual t test with p value
Summary
They are ubiquitously present in all biological systems on the cell surface as a complex array of sugar chains which are mainly conjugated to proteins and lipids. Sialic acid is one class of sugar which is located at the outermost end of glycan chains of all cell types.[3] Sialoglycans are involved in regulation of glycoprotein and glycolipid structure, stability, trafficking and they are mediators of wide variety of physiological and pathological processes. Sialic acid plays a significant role in cancer due to.
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