Abstract
Facial seborrheic dermatitis (FSD) is a common facial inflammatory dermatitis. Needle-free transdermal jet injection (NTJI) is a non-invasive injection of drug solution by using a high-pressure liquid injection instrument. To explore a safer, more tolerable, and convenient medical way using NTJI in the treatment of FSD, the patients were treated with vitamin B6, glycyrrhizin compound, metronidazole, and hyaluronic acid sequentially using NTJI every 2 weeks, and only those treated for more than three times were included. A VISIA facial imaging system for the evaluation of erythema, superficial lipid level, and roughness of skin surface and a CK analyzer for biophysical parameters, including the stratum corneum hydration, facial surface lipid, and trans-epidermal water loss, were applied. Erythema was significantly reduced after every treatment (weeks 2, 4, and 6; P < 0.05), whereas superficial lipid level was not improved significantly until week 6 (P < 0.05), and roughness of the skin surface was not improved significantly during the whole treatment. The stratum corneum hydration of lesional skin was significantly increased after three times of treatment (P < 0.05). No observable adverse effect, such as marked erythema, blistering, or atrophy, was observed. Sequential transdermal delivery of small molecular weight drugs (vitamin B6, glycyrrhizin compound, metronidazole, and hyaluronic acid) using NTJI is a safe, low-toxicity, and take-home drug-free therapy for the treatment of FSD.
Highlights
Facial seborrheic dermatitis (FSD), characterized by variable erythematous plaques with oily-yellow desquamation, is a common chronic inflammatory skin condition of the face with a high incidence and prevalence (1–3% in the general population, 3–5% in young adults, and 40–80% in HIVpositive individuals) [1]
In comparison with baseline data obtained before the first treatment, erythema was decreased significantly after every treatment, whereas the superficial lipid level was improved significantly in week 6 (P < 0.05) (Figures 2, 3), revealing that this treatment provided significant effect on improving the symptoms of erythema and skin sebum of FSD
The mean of stratum corneum hydration of lesional skin in FSD patients was significantly higher after three treatments (P < 0.05)
Summary
Facial seborrheic dermatitis (FSD), characterized by variable erythematous plaques with oily-yellow desquamation, is a common chronic inflammatory skin condition of the face with a high incidence and prevalence (1–3% in the general population, 3–5% in young adults, and 40–80% in HIVpositive individuals) [1]. Topical corticosteroids or other antiinflammatory ointments have been the mainstay of treatment, but their use has been limited by potential adverse effects such as irritation, telangiectasia, skin atrophy, and rebound after discontinuation [1]. A comprehensive approach for FSD should include cause-relative and epidermal barrier repairing. A typical formulary in the treatment of FSD should include antipruritics, anti-inflammatories, and skin barrier repairing. A combination of different therapies to treat FSD may be more effective and could be related to fewer adverse reactions as compared with monotherapy [2]
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