Abstract
The clinical effects of cefpirome (CPR) monotherapy were evaluated in 38 infected patients with hematological diseases. The underlying diseases of the patients were chiefly acute leukemia, myelodysplastic syndrome, malignant lymphoma, and aplastic anemia, and 18 patients were clinically neutropenic (<500 neutrophils/μL). Septicemia, pneumonia, or an unexplained fever, were the predominant complicating infections. The clinical efficacy of CPR was satisfactory or improved in 89.5% of patients. When compared to empirical combination therapy with 2 antibiotics, monotherapy with CPR reduced the drip infusion volume and the frequency of antibiotic administration, resulting in a better quality of life due to less frequent night urination, a low cost/benefit ratio, and reduction in nursing responsibilities. Due to this high efficacy rate, monotherapy with CPR should be considered as a front-line therapeutic approach in patients with infections accompanying hematological diseases, particularly those with neutropenia. J Infect Chemother 1996;2:75-78.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
