Abstract
A continuous infusion of glucagon in an average dose of 4 mg. per hour over several days produced distinct improvement in the clinical state of 12 of 16 patients. Improvement was noted by an increase in blood pressure and urinary output and decrease in dyspnea, pulmonary râles, diaphoresis, and peripheral edema when present. Serum potassium must be carefully monitored. The rise in blood glucose has not been a clinical problem. No cardiac arrhythmias were induced by glucagon, and as cardiac function improved, the heart rate usually decreased. Nausea was the most frequent side effect, but no toxic effects or tachyphylaxis were observed. Long-term therapy with glucagon infusion is both safe and highly efficacious in selected patients with severe cardiovascular disease states and is the treatment of choice in cardiac decompensation secondary to beta-blocking agents.
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