Abstract
Large numbers of local and systemic therapies are available for acne treatment. Common oral or topical retinoids, antibiotics, or keratolytics are used but sometimes are inconvenient, and side effects caused by these conventional therapies prompted a search for effective and safe treatments. This study aimed to evaluate the efficacy of intralesional platelet-rich plasma injection versus 1064 nm long-pulsed Nd:YAG laser in the treatment of moderate inflammatory acne vulgaris in both adolescents and post-adolescent patients. This split-face comparative study was carried out on thirty patients who suffered from moderate inflammatory and non-inflammatory acne vulgaris. The patients were classified into two groups: group I: adolescent (≤ 25 years) and group II: post-adolescent (< 25 years). Each group received four sessions of intralesional PRP injection on one side of the face and a long-pulsed Nd:YAG (1064 nm) laser on the other side with 2 weeks interval. Evaluation was done by blinded dermatologists using photographs and lesions counting and by patient satisfaction. Side effects were also noted. Both groups (adolescents and post-adolescent) showed a high statistically significant improvement of inflammatory as well as non-inflammatory lesions either in PRP or Nd:YAG laser–treated side with no significant difference between the two sides. The intralesional PRP injection and 1064 nm long-pulsed Nd:YAG laser are safe and effective methods for controlling inflammatory as well as non-inflammatory acne vulgaris in both adolescents and post-adolescent patients.
Highlights
Acne vulgaris is a common disorder of the pilosebaceous unit, affecting about 85% of persons 12 to 25 years of age [1]
This study aimed to evaluate the efficacy of intralesional platelet-rich plasma injection versus 1064 nm long-pulsed Nd:YAG laser in the treatment of moderate inflammatory acne vulgaris in both adolescent and post-adolescent patients
All patients aged more than 18 years with active moderate inflammatory acne vulgaris including the inflammatory papules and nodules that count from 6 to 20 lesions in each half of the face according to Hayashi score [7]
Summary
Acne vulgaris is a common disorder of the pilosebaceous unit, affecting about 85% of persons 12 to 25 years of age [1]. It often persists into adulthood, in 12–14% of cases with psychological, social, and emotional impairments [2]. Such a condition affecting wide range of population and leaving a permanent sequel needs effective management strategy that targets multiple pathogenic factors. Laser therapy has been widely used in the treatment of acne vulgaris due to its effectiveness and safety as it provides a more rapid response with less rate of recurrence, 1064 nm Nd:YAG laser that has been documented in many studies [3, 4]
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