Clinical evaluation of analgesics against pulsating pain in dental diseases

Abstract

To investigate the effect of analgesics on pulsating pains, we studied the effect of pyrazolone and salicylate analgesics on the onset time and duration of analgesia, the course of analgesics response, and the recurrence of pain. The overall effective rate was 90.2%, 97.4% for the pyrazolone analgesics tested and 83.3% for the salicylate analgesics. In the pyrazolone group, the onset time and duration of analgesia were shorter than in the salicylate group. The time course of analgesics response was as follows: Fifteen minutes after ingestion of the pyrazolone analgesics, “severe” pain was reduced to “moderate” or “mild” in half of the patients; By 60 min after ingestion “severe” and “moderate” pains had disappeared; and the maximum analgestic effect was attained 120 min after ingestion. In the salicylate group, pains disappeared with time, starting from 30 min after ingestion. When compared by the type of wounds, the effective rate was higher on open wounds. The pyrazolone analgesics were more effective on both types of wounds, and also had a tendency to exert a higher analgesic effect on both the pulp disease and the disease of tooth supporting tissue.