Abstract
ABSTRACTObjective: To analyze the current scientific literature to document, in an integrative review, the main findings that correlate Kawasaki disease (KD) to COVID-19.Data sources: The search was carried out in June 2020 in the following databases: Biblioteca Virtual em Saúde (BVS), periódico da CAPES and U.S National Library of Medicine (PubMed). The combination of descriptors used was [(COVID-19 OR SARS-CoV-2) AND (Kawasaki disease)], and the inclusion criteria stipulated were studies published from January 2019 to June 2020, without restriction of language or location, and available online in full. News, editorials, comments, and letters, as well as duplicates and articles that did not answer the guiding question were excluded.Data synthesis: A total of 97 articles were identified, of which seven comprised this review. The association of KD to the new coronavirus appears to trigger a severe clinical condition of vasculitis. Different from the usual, in this inflammatory syndrome, patients are older, and prevalence is higher in children from African or Caribbean ancestry; clinical and laboratory manifestations are also atypical, with a predominance of abdominal complaints and exaggerated elevation of inflammatory markers. In addition, there was a greater report of rare complications and greater resistance to the recommended treatment for KD.Conclusions: Pediatric COVID-19 and its potential association to severe KD, still unfamiliar to health professionals, reinforces the importance of testing patients with vasculitis for the new coronavirus and the need to wage high surveillance and preparation of the health system during the current pandemic.
Highlights
The new severe acute respiratory syndrome coronavirus (SARS‐CoV-2) was identified in Wuhan, China, in late 2019, as the cause of COVID-19 and soon became a global health emergency
Children infected with SARS-CoV-2 have developed a severe condition of inflammatory syndrome sim‐ ilar to Kawasaki disease (KD), leading to an unusual 30-fold increase in the incidence of this pathology.[6]
This review aims to eluci‐ date, based on scientific papers published to date, the relation between SARS-CoV-2 and KD
Summary
The new severe acute respiratory syndrome coronavirus (SARS‐CoV-2) was identified in Wuhan, China, in late 2019, as the cause of COVID-19 and soon became a global health emergency. It affects 1.5 to 7% of patients, and should be identified early, because it can progress to shock with strong inflammatory responses that result in coronary artery disease and multiple organ dysfunc‐ tion.[12,13] rare, these complications, when associated with COVID-19, seem to be more prevalent.[14,15]
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