Clinical Efficacy of Using Anti-Adhesion Fluid to Flush Fallopian Tube After Recanalization Surgery

Abstract

Objective To investigate the impact of using surgical anti-adhesion fluid to flush fallopian tube after blocked fallopian tubal recanalization surgery on post-operative tubal patency and pregnancy rate. Methods From April 2005 to April 2008, 208 cases were diagnosed as infertility were recruited in the Department of Obstetrics and Gynecology, Second People's Hospital of Ya'an City. They were divided into treatment group (n=105) and control group (n=103). Informed consent was obtained from all patients. There were no significant differences in mean age, situation of fallopian tube jam, infertility type and duration of infertility between two groups (P>0.05). Both two groups underwent fallopian tube recanalization for block tubes. In treatment group, after the procedure, surgical anti-adhesion flushing fluid (carboxymethyl chitosan and balanced salt solution, 20 mL) was injected into the fallopian tubes and pelvic, while control group received a-chymotrypsin, gentamicin and dexamethasone to prevent postoperative adhesions. Follow-up observation of 1-2 months of patency rate and postoperative pregnancy rate [positive rate of human chorionic gonadotrophin(hCG) and ultrasound positioning]. Results In treatment group, the blocked fallopian tubal re-patency rate immediately after surgery was 95.8% (162/169), and in control group was 96.3%(160/166). The blocked fallopian tubal re-patency rate immediately after surgery had no significant difference of two groups(P>0.05). In 1-2 months after surgery, the tube patency rate and an overall pregnancy rate between treatment group and control group was 95.1% (98/103) vs. 86.2% (88/102), and 40.1% (41/102) vs. 35.3% (35/99). They had significant difference in patency rate and postoperative pregnancy rate between two groups (P<0.05). Conclusion After blocked fallopian tube recanalization, surgical anti-adhesion fluid to flush may be effective to reduce the recurrence rate of postoperative adhesions block and improve pregnancy rate. Key words: blocked fallopian tubal recanalization surgery; anti-adhesion flushing fluid; recurrent adhesions