Abstract
In this study, we evaluated the efficacy of intravoxel incoherent motion (IVIM)-derived parameters calculated with three b-values in differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs) by comparing those calculated with multiple b-values. Ten patients with LGG (ages 35.1±12.1 yrs; 4 males, 6 females) and 21 patients with HGG (ages 60.6±19.1 yrs; 10 males, 11 females) who underwent subsequent surgical resections were examined with both IVIM imaging and histopathological analysis. The IVIM diffusion-weighted imaging was conducted using a single-shot echo planar sequence with 13 b-factors (0, 10, 20, 30, 50, 80, 100, 200, 300, 400, 600, 800, and 1000 sec/mm2) at 3T. In the conventional IVIM analysis, the perfusion fraction (f) and true diffusion coefficient (D) were calculated by biexponential fitting model with 13 b-values. In the simplified method with the selected three b-values (0, 300, and 1000 sec/mm2), D simply corresponds to the slope of a straight line passing through two logarithmic signal intensities (SIs) at the b-values of 300 and 1000 s/mm2, and f corresponds to the difference between the intercept of this line and SI at the b-value of 0 sec/mm2. The maximum f (f-max) and minimum D (D-min) was measured in each tumor. The f-max values calculated with three b-values (12.8±5.9%) were significantly lower than those with 13 b-values (17.3±7.5%, p<0.0001), but a good correlation and agreement were observed between these sets of f-max values (r = 0.79, ICC = 0.87). In the IVIM imaging with both three and 13 b-values, the HGGs showed significantly higher f-max values compared to the LGGs (p<0.001, respectively). The D-min values calculated with three b-values (1.06±0.31 ×10−3 mm2/sec) was not different from those with 13 b-values (1.07±0.33 ×10−3 mm2/sec), and an excellent correlation and agreement were found between them (r = 0.99, ICC = 0.99). The simplified IVIM imaging using three b-values can efficiently differentiate HGGs and LGGs.
Highlights
Glioma is a common tumor that arises from glial cells of the central nerve system [1, 2]
The f-max values calculated with the three b-values (12.8±5.9%) were significantly lower than those calculated with the 13 b-values (17.3±7.5%, p
The f-max values calculated with three b-values showed good agreement with those obtained using 13 b-values, the former were lower values
Summary
Glioma is a common tumor that arises from glial cells of the central nerve system [1, 2]. Dynamic susceptibility contrast (DSC) perfusion-weighted (PW) imaging can provide information related to tumor vascularity, which is another important histopathological feature, and DSC-PW imaging has been used in the assessment of gliomas [11]. IVIM was defined as the microscopic translational motions of water molecules that occur in each image voxel in MR imaging [14] Such motions include water diffusion and microcirculations of blood in capillaries (perfusion) in in vivo tissues. Sumi et al reported that perfusion-related parameters that correspond to f-values calculated with three b-values were useful in differentiating the types of head and neck tumors [22]. We conducted the present study to determine the efficacy and diagnostic performance of IVIM-derived parameters calculated with three b-values in differentiating HGGs from LGGs by comparing to those with multiple b-values
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