Abstract
Purpose: To study the clinical efficacy of semiconductor laser-assisted minocycline in the treatment of moderate-to-severe chronic periodontitis (CP) in type 2 diabetes mellitus (T2DM) patients.Methods: A total of 109 cases of CP combined with T2DM and obesity admitted to The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi’an, China, from November 2016 to November 2017 were included in the study. Among them, 54 patients in the study group were treated with semiconductor laser-assisted minocycline, while 55 patients in the control group were treated with minocyclin injection. Periodontitis, blood glucose and blood lipid levels were compared between the two groups before and after treatment.Results: Post-treatment (12 weeks), bleeding on probing, gingival index, periodontal probing depth (PD), plaque index (PLI), clinical attachment loss (CAL), and sulcus bleeding index (SBI) in the two groups of patients were significantly improved (p < 0.05). The levels of PD, BOP, PLI, and CAL in the positive SBI group (4.06 ± 0.25, 20.37 %, 0.50 ± 0.28, 3.42 ± 0.27, and 1.43 ± 0.26, respectively) were significantly lower than the corresponding levels in the control group (p < 0.05. Fasting plasma glucose (FPG) and HbA1c for the two groups were significantly improved, when compared with values prior to treatment (p < 0.05), but there was no significant difference in FPG level between the two groups. Significantly lower HbA1c levels were found in the treatment group than in the control group (t = 4.2360, p = 0.0001). Post-treatment, triglyceride (TG), total cholesterol (TC) and body mass index (BMI) did not improve significantly in the two groups, nor were there significant differences in these parameters before and after treatment (p > 0.05).Conclusion: Semiconductor laser-assisted minocycline is effective in treating moderate and severe chronic periodontitis patients with type 2 diabetes, and can improve blood glucose. However, its effect on body weight needs further studies.Keywords: Semiconductor laser, Minocycline, Chronic periodontitis, Type 2 diabetes, Obesity
Highlights
CP continuously destroys the periodontium under the effect of multiple factors and usually gives rise to loss of teeth at the last stage [1]
Chronic periodontitis has become a major complication of DM [5]
There was no significant difference in gingival index (GI) between the two groups (t = 0.6920, p = 0.4913)
Summary
CP continuously destroys the periodontium under the effect of multiple factors and usually gives rise to loss of teeth at the last stage [1]. A total of 109 CP patients with T2DM and obesity, admitted in our hospital from November 2016 to November 2017, were recruited for investigating the clinical efficacy of semiconductor laser-assisted minocycline therapy. In addition to periodontal nonsurgical treatment and minocycline, the study group received auxiliary semiconductor laser (Sirona, Germany, wavelength 980 nm, power 2 w), zig-zagged on periodontal pocket. The inclusion criteria were: (1) eligibility for the diagnosis of chronic periodontitis [7]; eligibility for the diagnosis of type 2 diabetes mellitus (T2DM); (3) obesity with BMI > 28; (4) age > 18 years; (5) regular hypoglycemic treatment for diabetes for stable blood glucose control; and (6) signing of an informed consent. All data were analyzed by software SPSS 18.0. Values of p < 0.05 were taken as indicative of significant difference between the effect of semiconductor laser-assisted minocycline treatment and the injection of minocycline alone
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