Abstract
Purpose: To assess the clinical efficacy and side effects of radiotherapy combined with sodium glycididazole in the treatment of recurrent esophageal carcinoma.Methods: Ninety patients with locally recurrent oesophageal carcinoma who were admitted to the Oncology Department at Taian City Central Hospital, Shandong, China, were randomly divided into a treatment group (treated with radiotherapy and sodium glycididazole) and a control group (treated with radiotherapy alone) in a randomized study. Short-term curative effects, median progression-free survival (PFS), and side effects were compared between the two groups.Results: The cure rate in the treatment group was 86.70 %, whereas that in the control group was 51.10 % (p < 0.05). Median PFS in the treatment group was 9.9 months versus 5.3 months in the control group (p < 0.05). Side effects in both groups included alopecia, headache, nausea, vomiting and leucopaenia, at level one or two. In this regard, the difference between the two groups was statistically insignificant (p > 0.05).Conclusion: Radiotherapy combined with sodium glycididazole shows a higher short-term curative effect in the treatment of recurrent oesophageal carcinoma than radiotherapy alone.Keywords: Alopecia, Leucopaenia, Oesophageal carcinoma, Radiotherapy, Sodium glycididazole
Highlights
Oesophageal carcinoma is a common gastrointestinal tract cancer and has high morbidity and mortality among malignant cancers [1,2]
Patients were divided randomly into a treatment group (45 patients treated with radiotherapy and sodium glycididazole) and a control group (45 patients treated with radiotherapy alone)
Patients in the treatment group were treated with radiotherapy and sodium glycididazole; those in the control group were treated with radiotherapy alone
Summary
Oesophageal carcinoma is a common gastrointestinal tract cancer and has high morbidity and mortality among malignant cancers [1,2]. Surgery is the major treatment method for oesophageal cancer [3,4]. More than 40 % of patients are likely to have mediastinal lymph node metastasis or anastomotic recurrence after undergoing radical resection for oesophageal carcinoma, but it is often difficult for recurrent patients to undergo further surgery; radiotherapy becomes the main treatment method [7]. One of the main factors influencing radiotherapeutic efficacy is the insensitivity of 10 – 50 % of hypoxic cells in a solid carcinoma to low linear energy transfer (LET) rays [8]. The only formally clinically used radiosensitiser with high efficacy and low toxicity, is a safe and effective radiosensitiser for hypoxic cells. We treated recurrent oesophageal cancer using radiotherapy combined with sodium glycididazole and obtained significant short-term effects
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