Abstract
ObjectiveThe objective of this study was to investigate and compare the effectiveness of several toothpastes containing nanohydroxyapatite (nano-HAP) to relieve dentin hypersensitivity (DHS) with that of a commercial desensitizing dentifrice containing calcium sodium phosphosilicate (CSPS).Materials and methodsIn this double-blind, randomized, parallel-group clinical trial, patients diagnosed with DHS and qualified to participate were randomized into four groups: toothpaste containing 10% nano-HAP (10%nano-HAP), 15% nano-HAP (15%nano-HAP), 10% nano-HAP supplemented with potassium nitrate (KNO3) (10%nano-HAPKN), or CSPS. Subjects’ baseline and post-treatment sensitivities were assessed using visual analog scale (VAS) after the application of ice-cold and air stimuli. Subjects used their assigned toothpaste for routine toothbrushing twice daily. Post-treatment sensitivity was assessed every 2 or 8 weeks. Mean change in VAS (mm) from baseline at each time point were compared using random-intercept, mixed-model analysis and Duncan test (P < 0.05).ResultsWith either air or cold stimulus, VAS indicated a significant (P < 0.001) reduction from baseline DHS at each time point with all test toothpastes. Among the nano-HAP toothpastes, 15%nano-HAP and 10%nano-HAPKN were consistent in DHS reduction with both stimuli. With either stimuli, the CSPS did not significantly differ from 15%nano-HAP and 10%nano-HAPKN at any time point.ConclusionsToothpaste containing nano-HAP (10 or 15%) alone or supplemented with KNO3 was as effective as CSPS for relief of DHS symptoms when used at least twice daily.
Highlights
Dentin hypersensitivity (DHS) is a common clinical condition characterized by transient, sharp pain arising from exposed tooth dentin in response to external stimuli, typically thermal, evaporative, tactile, electrical, osmotic, or chemical, that cannot be attributed to any other dental disease.[1]
The clinical trial to test the ability of toothpaste containing varying visual analog scale (VAS), which was well explained to the subjects, consists of an percentages of nano-HAP to relieve the symptoms of DHS
10% Nano-HAP toothpaste 15% Nano-HAP toothpaste Nano-HAP supplemented with potassium nitrate SensodyneTM Repair & Protect with NovaMin® Colgate Cavity Protection® outcomes at each time point were compared using the Duncan test for multiplicity with unequal sample sizes at 5% confidence interval
Summary
Dentin hypersensitivity (DHS) is a common clinical condition characterized by transient, sharp pain arising from exposed tooth dentin in response to external stimuli, typically thermal, evaporative, tactile, electrical, osmotic, or chemical, that cannot be attributed to any other dental disease.[1]. The most commonly affected teeth are the maxillary and mandibular canines and premolars, with the cervical area of the buccal surface being the most affected tooth region.[2]
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