Clinical efficacy of low dose 5-fluorouracil with triamcinolone for treatment of keloids

Abstract

Objective To evaluate the efficacy of low dose 5-fluorouracil (5-Fu) combined with triamcinolone in the treatment of keloids, comparing with results with use of triamcinolone treatment alone. Methods Patient records from 2012 to 2013 were reviewed. 45 patients (56 keloids) were completely randomized into 2 groups. Low dose of 5-Fu combined with triamcinolone were used to treat keloids in group A, while triamcinolone alone was used in group B. The therapeutic effects were evaluated by the certification of excellent remission, remission, inefficacy and total efficacy. The results were analyzed with statistics. Results In group A (27 keloids), the excellent remission cases were 16 (59.3%), the remission cases were 9 (33.3%), and the inefficacy cases were 2 (7.4%). The total percentage of efficacy in group A was 92.6%. In group B (29 keloids), the excellent remission cases were 9 (31.0%), the remission cases were 12 (41.4%), and the inefficacy cases were 8 (27.6%). The total therapy efficacy percentage of group B was 72.4%. Both the total percentage of efficacy and the excellent remission percentage in group A were apparently higher than those of group B, and the differences between the two groups were of statistical significance (P<0.05). The recurrence rates of group A were 3.7% (one case) while that of group B were 24.1% (7 cases). The differences between the two groups were also of statistical significance (P<0.05). Conclusions Low dose 5-Fu combined with triamcinolone is superior to intralesional triamcinolone therapy alone in the treatment of keloids. Key words: Keloid; 5-Fluorouracil; Triamcinolone