Clinical Efficacy of Kangguzeng Capsule Combined with Basic Anti Osteoporosis Drugs in the Treatment of Postmenopausal Osteoporosis

Abstract

Objective: To investigate the clinical efficacy of kangguzeng capsule combined with basic anti osteoporosis drugs in the treatment of postmenopausal osteoporosis. Methods: 96 patients who met the inclusion criteria in the First Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from June 2020 to June 2021 were included in the study. According to the random number table, the patients were divided into treatment group (48 cases) and control group (48 cases). The control group was treated with basic anti osteoporosis drugs, including alendronate sodium and calcitriol capsules; the treatment group was given kangguzeng Capsule on the basis of the control group. The patients were followed up regularly, and the TCM clinical syndrome score, pain visual analogue score (VAS), serum type I procollagen amino terminal propeptide (PINP) and type I collagen carboxyl terminal peptide were observed and recorded (β- CTX) and other indicators. Results: the clinical syndrome scores of the treatment group and the control group were improved. Compared with those before treatment, the clinical syndrome scores of the treatment group and the control group decreased significantly after treatment, and the difference was statistically significant (P < 0.05). The score of the treatment group was significantly better than that of the control group after treatment, and the difference was statistically significant (P < 0.05); In terms of VAS score, compared with that before treatment, the VAS score of the treatment group and the control group decreased significantly after treatment, and the difference was statistically significant (P < 0.05). The score of the treatment group after treatment was significantly better than that of the control group after treatment, and the difference was statistically significant (P < 0.05); In terms of PINP, the PINP of the treatment group and the control group were significantly higher than that before treatment (P < 0.05). The PINP of the treatment group was significantly higher than that of the control group after treatment (P < 0.05); stay β- In terms of CTX, the treatment group and the control group were compared after treatment and before treatment, β- CTX decreased significantly, and the difference was statistically significant (P < 0.05) β- CTX and control group after treatment β- There was significant difference in CTX (P < 0.05).Conclusion: kangguzeng capsule combined with basic anti osteoporosis drugs is effective in the treatment of postmenopausal osteoporosis. It can improve the clinical symptoms, biochemical indexes of bone metabolism and bone mineral density, and improve the quality of life of patients.