Abstract
To evaluate the effectiveness of high-flow nasal humidified oxygen (HFNHO) therapy in patients with mild hypoxemia after extubation. This study included 316 patients with mild hypoxemia after extubation from May 2016 to May 2018 from two intensive care units in China. Compare the effects of the Venturi Mask and High-Flow Nasal Humidified Oxygen (HFNHO) therapy on Heart Rate (HR), Respiratory Rate (RR), Oxygen Saturation (SpO2), Oxygen Partial Pressure (PO2), Partial Pressure Of Carbon Dioxide (PCO2), Oxygenation Index (PO2/FiO2) after extubation, the use of noninvasive mechanical ventilation and tracheal intubation after treatment failure were observed and recorded. Patients have both lower HR and RR than those who received mask treatment (75.4±18.5 vs. 83.0±20.4, p = 0.0004; 18±6.5 vs. 23.6±10.3, p<0.001, respectively). There was significant difference between those who had HFNHO and mask administration’s SpO2 and PO2 (94.1±6.4 vs. 87.5±1.5, p<0.001; 88.16±2.9 vs. 77.3±2.3, p<0.001, respectively). For the HFNHO group, patients had lower PCO2 with the mask group. (41.3±0.99 vs 42.2±1.2, p<0.001). On the other hand, the levels of PO2/FiO2 was significantly higher in the HFNHO Group, (181.0±8.3 vs. 157.2±4.9, p<0.05). We concluded HFNHO therapy could significantly relieve the symptoms of dyspnea, improve oxygenation, reduce the use of noninvasive mechanical ventilation and reduce the rate of secondary tracheal intubation in patients with mild hypoxemia after extubation.
Highlights
The overall goal of oxygen therapy administration is to maintain adequate tissue oxygen supply, high-flow nasal humidified oxygen (HFNHO) therapy refers to a novel noninvasive ventilation and oxygen therapy method that uses a high flow of air containing a certain concentration of oxygen; compare to the regular invasive ventilation, HFNHO shows its superiority in the direct air supplied to patients via nasal cannulas that are not necessarily airtight [1,2,3,4]
This study aimed to investigate the correlation between HFNHO therapy and the frequency of noninvasive ventilation and the proportion of patients who received secondary tracheal intubation
All patients underwent physical examination, including anthropometric measures, body mass index (BMI) was calculated, laboratory testing, level of serum sodium (Na), potassium (K), hemoglobin, C-reactive protein (CRP), brain natriuretic peptide (BNP), echocardiography, and there were no significant differences in the age and gender distribution between the examined subgroups (Table 1)
Summary
The overall goal of oxygen therapy administration is to maintain adequate tissue oxygen supply, high-flow nasal humidified oxygen (HFNHO) therapy refers to a novel noninvasive ventilation and oxygen therapy method that uses a high flow of air containing a certain concentration of oxygen; compare to the regular invasive ventilation, HFNHO shows its superiority in the direct air supplied to patients via nasal cannulas that are not necessarily airtight [1,2,3,4]. Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia of 21–100% at a temperature of approximately 37 ̊C and a relative humidity of 100%[5,6,7], ensure normal airway mucociliary function and promote the elimination of sputum[8]. This study aimed to investigate the correlation between HFNHO therapy and the frequency of noninvasive ventilation and the proportion of patients who received secondary tracheal intubation
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