Clinical efficacy of Dobronos nasal filters in complex allergic rhinitis therapy

Abstract

Allergic rhinitis (AR) is a wide spread chronic respiratory disease requiring prolonged anti-inflammatory treatment. AR exacerbations follow the contact with allergen / allergens. We evaluate nasal filters efficacy in complex AR of mild and moderate severity therapy in patients with house dust and animal dander sensitization. 6-week open study included 50 patients 5 to 42 years old. The study included 2-week enrollment and 4-week treatment periods. 46 patients completed the treatment period, 3 were excluded due to nasal discomfort during filter use, and one patient due to non-compliance. In mild AR patients we revealed significant reduction in all AR symptoms according to the TNSS scale. In moderate AR patients we found significant reduction in nasal itch and sneezing only. In comparison with the enrollment period, the number of days with as-needed antihistamine intake reduced and the number of symptom-free days increased significantly in both mild and moderate AR groups. Nasal protective filters can be recommended for complex therapy in mild and moderate AR in most patients.