Clinical Efficacy of Different Thoracoscopic Surgeries for Patients With Non-small Cell Lung Cancer.

Tao Wang,Xi Liu,Tao Liang,Lei Chen,Xiaokuang Ning

doi:10.3389/fsurg.2022.842047

Abstract

BackgroundThe aim of this study was to analyze the clinical efficacy of different thoracoscopic procedures in patients with non-small cell lung cancer and their correlation with matrix metalloproteinase-7 mRNA (MMPs-7 mRNA) and soluble major histocompatibility complex class I molecule A (sMICA), as well as their effect on T-cell subsets.MethodsA total of 100 patients with non-small cell lung cancer who received different thoracoscopic surgeries were divided into the Control group (three-port thoracoscopic surgery) and the study group (single-port thoracoscopic surgery). The two groups were evaluated to compare the perioperative indicators, MMPs-7 mRNA, sMICA expression levels, T-cell subsets, postoperative pain, complication rates, and prognostic outcomes at 1-year follow-up.ResultsThe operation time, blood loss, drainage tube placement time, incision length, and hospital stay in the study group were less than those in the control group (P < 0.05). There was no significant difference in the number of lymph node dissections between the two groups (P > 0.05). After 3 days, the expression levels of MMPs-7 mRNA and sMICA in the study group were lower than those in the control group (P < 0.05); CD4 +, CD8 +, and CD4 +/CD8 + in the study group were higher than those in the control group (P < 0.05). On days 1, 3, and 5, the visual analog score (VAS) of the study group was lower than that of the control group (P < 0.05); there was no significant difference in the complication rate between the two follow-up groups (P > 0.05), in which all patients completed the follow-up. After 1 year of follow-up, there was no significant difference in the tumor-free survival rate and overall survival rate between the two groups (P > 0.05).ConclusionCompared with three-port thoracoscopic surgery, single-port thoracoscopic surgery can improve perioperative expression, shorten hospital stay, reduce serum tumor micrometastasis levels, improve immune metastasis mechanisms and reduce pain, which is of great significance to patients with non-small cell lung cancer. It is an effective, convenient, and safe surgical option that deserves wide clinical reference.

Highlights

Surgery, chemoradiotherapy, and other treatments are mostly advocated in clinical practice, of which surgery can play an ideal role in early cell lung cancer
Metalloproteinase-7 mRNA (MMPs-7 mRNA), soluble major histocompatibility complex class I molecule A, and T-cell subsets are correlated with lung cancer staging and prognosis
This study analyzed the clinical efficacy of different thoracoscopic procedures for nonsmall cell lung cancer patients and their effects on MMPs7mRNA, sMICA, and T-cell subsets to provide a theoretical basis for the subsequent clinical selection of the appropriate surgical approach

Summary

Introduction

Lung cancer has become one of the malignant tumor diseases that seriously endanger human health and safety in China, and the incidence rate is increasing year by year. Metalloproteinase-7 mRNA (MMPs-7 mRNA), soluble major histocompatibility complex class I molecule A (sMICA), and T-cell subsets are correlated with lung cancer staging and prognosis. This study analyzed the clinical efficacy of different thoracoscopic procedures for nonsmall cell lung cancer patients and their effects on MMPs7mRNA, sMICA, and T-cell subsets to provide a theoretical basis for the subsequent clinical selection of the appropriate surgical approach. The aim of this study was to analyze the clinical efficacy of different thoracoscopic procedures in patients with non-small cell lung cancer and their correlation with matrix metalloproteinase-7 mRNA (MMPs-7 mRNA) and soluble major histocompatibility complex class I molecule A (sMICA), as well as their effect on T-cell subsets

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