Abstract
Objective To explore the clinical efficacy ofaripiprazole in treating patients with schizophrenia complicated with depressive symptoms and its influence in life quality improvement.Methods A total of 88 schizophrenic patients with depressive symptoms who met the ICD-10 diagnostic criteria and had HAMD scores higher than 18,admitted to our hospital from January 2011 to June 2012,were randomly divided into aripiprazole treatment group (n=44) and risperidone treatment group (n=44); these patients were treated with aripiprazole or isperidone,respectively,for 24 weeks.Psychiatric symptoms were assessed with positive and negative syndrome scale (PANSS),depressive symptoms were assessed with Hamilton Rating Scale for Depression (HAMD) and clinical efficacy was assessed with Clinical Global Impression-Severity Index (CGI-SI) at the baseline and 4th,12th and 24th week of treatment.Improvement of life quality was assessed with WHO quality of life (QOL)-100 at the baseline and 24th week of treatment.Results The total scores of PANSS,positive symptom scale,negative symptom scale,general psychopathology scale,CGI-SI,QOL-100 and HAMD scale showed no significant differences between the two groups at the baseline (P＞0.05).The scores of positive symptom scale,CGI-SI and HAMD scale four weeks after treatment,the scores of negative symptom scale 12 and 24 weeks after treatment,the scores of QOL-100 and HAMD 24 weeks after treatment showed significant differences between the two groups (P＜0.05).Except the negative symptom scale scores in the aripiprazole treatment group 4 weeks after treatment and HAMD scale scores 4 weeks after treatment in the risperidone treatment group,all the other scale scores at all different observation time points showed significant difference as compared with those before treatment (P＜0.05).Conclusion As one of the third generation antipsychotics,aripiprazole can relieve the negative and depressive symptoms in schizophrenia patients positively,and improve the quality of life. Key words: Aripiprazole; Risperidone; Schizophrenia; Depressive symptom; Clinical efficacy; Quality of life
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