Abstract
BackgroundThis study aimed to study the clinical efficacy of argon plasma coagulation plus cryotherapy for central airway stenosis caused by lung cancer.MethodsThe clinical data of 177 patients with central airway stenosis caused by lung cancer received surgery from June, 2017 to July 2018 were retrospectively analyzed. According to different treatments, 43 patients received cryotherapy were included in the control group, while 134 patients received argon plasma coagulation plus cryotherapy were in the observation group. After propensity score matching, patients in the two groups were in a 1:1 ratio. The Karnofsky score, partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2), partial pressure of arterial carbon dioxide (PaCO2) and adverse reactions in patients were analyzed one week before and after treatment. Besides, the survival rates of the two groups were compared.ResultsAfter propensity score matching, the baseline data were not significantly different between the two groups. The post-treatment Karnofsky scores in the two groups were significantly higher than those of before treatment, and the post-treatment score of the observation group was higher than that of the control group (all P < 0.05). The post-treatment PaO2 and SaO2 in the observation group were both higher than those of the control group; while the PaCO2 in the observation group was significantly lower than that of the control group (all P < 0.05). In the observation group, the levels of PaO2 and SaO2 were significantly higher, and the level of PaCO2 was significantly lower after treatment than those of before treatment (all P < 0.05). The rates of completely effective and mild effective in the observation group were significantly higher than those in the control group (both P < 0.05). The incidences of bleeding, arrhythmia and fever in the observation group were significantly lower than those in the control group (all P < 0.05). The survival rate was significantly higher in the observation group (72.09%) than in the control group (51.16%).ConclusionsArgon plasma coagulation combined with cryotherapy can significantly alleviate the central airway stenosis caused by lung cancer, reduce the incidence of adverse reactions, and improve prognosis in patients.
Highlights
This study aimed to study the clinical efficacy of argon plasma coagulation plus cryotherapy for central airway stenosis caused by lung cancer
According to different treatment method, 43 patients received cryotherapy were included in the control group, while 134 patients received argon plasma coagulation plus cryotherapy were included in the observation group
Analysis of baseline data At baseline, there were statistically significant differences in BMI, nutritional status, airway obstruction and concomitant hypertension between the observation group and the control group, while there was no significant difference in gender, age, site of airway obstruction, pathological type, concomitant anemia, or tumor-node-metastasis (TNM) stage between the two groups
Summary
This study aimed to study the clinical efficacy of argon plasma coagulation plus cryotherapy for central airway stenosis caused by lung cancer. Lung cancer is currently with a high clinical incidence, and most patients did not realize the cancer until advanced stage due to its atypical symptoms. At this stage, patients may suffer symptoms such as central airway stenosis, shortness of breath, hemoptysis, and cough [1]. Study in 47 patients with tumor-induced central airway stenosis treated by argon plasma coagulation plus cryotherapy showed improved or disappeared symptoms such as dyspnea, cough, and hemoptysis, as well as significantly improved respiratory function in patients [8]. Argon plasma coagulation combined with cryotherapy were used to treat central airway stenosis caused by lung cancer, so as to analyze the effect of the combination on central airway stenosis
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