Clinical efficacy, complications and quality of life of radiotherapy combined with endocrine therapy for advanced prostate cancer

Abstract

Objective To explore clinical efficacy, complications and quality of life of the radiotherapy combined with endocrine therapy for advanced prostate cancer. Methods From April 2012 to April 2014, 86 cases of advanced prostate cancer patients in our hospital were selected as the research object. According to the different treatment methods, all patients were randomly divided into observation group (43 cases) and control group (43 cases), the control group was treated with three-dimensional conformal radiation treatment, observation group received radiotherapy combined with endocrine treatment.Clinical efficacy after treatment, complications and quality of life were compared between the two groups. Results The observation group after complete remission accounting for 37.21%(16/43), the total effective 62.79% (27/43) was significantly higher than the control group 16.28% (7/43), 34.88% (15/43)(P<0.05). Two group of patients had complications after treatment, but the total complication rate of observation group was significantly lower than the control group (P<0.05). The indexes of the two groups before treatment patients with expanded prostate cancer index composite(EPIC) had no significant difference, after treatment of each index of two groups of patients with EPIC decreased significantly, and the observation group decreased more significantly than the control group (P<0.05). Serum PSA and maximum urinary flow rate of two groups of patients before treatment were no significant difference between the two groups after treatment, PSA was significantly lower than before treatment, and the maximum urine flow rate compared with before treatment were significantly increased, but the observation group improved significantly better than the control group (P<0.05). Conclusions Radiotherapy combined with endocrine therapy has some advantages on the clinical efficacy of advanced prostate cancer, complications reduction, and improvement of survival quality, and effectively reduces the level of serum PSA and improves maximum urinary flow rate. Key words: Prostatic Neoplasms; Radiotherapy; Quality of Life