Abstract
Infancy hemangiomas (IHs) are the most common benign tumor of infancy.Earlytherapy has been recommended for proliferating IHs to prevent serious complications.As a non selective beta-adrenergic receptor antagonist,propranolol is commonly used in clinical practice.Recently,more and more studies have reported that propranolol has a good efficacy in the treatment of IHs.The possible therapeutic mechanisms of propranolol in IH include suppression of vascular endothelial growth factor (VEGF) production,inhibition of the hypoxia-inducible factor I (HIF-1) a-VEGF-A axis,downregulation of matrix metalloproteinases (MMPs) and endothelial nitric oxide synthase,and so on. Key words: Hemangiomas ; Infancy ; Propranolol
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