Clinical efficacies of oxybutynin plus transcutaneous electrical nerve stimulation for boys with overactive bladder after posterior valve ablation

Abstract

Objective To evaluate the efficacies of oxybutynin plus transcutaneous electrical nerve stimulation (TENS) for boys with overactive bladder (OAB) after posterior valve ablation. Methods From January 2010 to January 2015, a total of 112 PUV boys underwent endoscopic ablation. And 48 OAB boys were randomly divided into oxybutynin, TENS and combination groups. Oxybutynin group received oxybutynin alone, TENS group received TENS alone and combination group had both for 4 weeks.The efficacy was evaluated by urodynamic test. Results Detrusor uninhibited contraction duration (DUCD)(8.4±4.5) s was significantly lower in combination group than that in oxybutynin group (P<0.05). However, maximal voided volume was significantly higher in combination group than that in oxybutynin group [(103.4±31.5) ml vs(87.4±36.6) ml]. And maximal detrusor uninhibited contraction pressure(MDUCP) and detrusor uninhibited contraction duration(DUCD)were significantly lower than those in TENS group (15.5±5.3) cmH2O vs (26.7±9.5) cmH2O; (8.4±4.5) s vs (18.5±7.9) s. Conclusions Oxybutynin plus TENS may be efficacious for boys with overactive bladder after posterior valve ablation. Key words: Electric stimulation, transcutaneous; Oxybutynin; Posterior urethral valves; Bladder overactive