Clinical Effects of Shugan Jieyu Capsule Combined with Aerobic Exercise on Depression

Abstract

This study explored the clinical effect of Shugan Jieyu capsule combined with aerobic exercise on depression. One hundred patients with depression were recruited from Zhengzhou Sixth People’s Hospital and were divided into a control group (n = 50) and a research group (n = 50). Patients in the control group received escitalopram alone therapy, while the research group received escitalopram and Shugan Jieyu capsule in conjunction with aerobic exercise. The research group exhibited a better therapeutic effect than the control group (χ2 = 6.06). After therapy, the Hamilton Depression Rating Scale scores of both groups were reduced, and the research group had a lower score than the control group. Following treatment, tumor necrosis factor-α, interleukin-6, and interleukin-2 levels decreased in both groups, and the research group had lower levels than the control group. The Pittsburgh Sleep Quality Index scores of both groups were reduced, with the research group having a lower score than the control group. The score for each item of the World Health Organization Quality of Life in both groups was elevated after therapy, and the research group had a higher score than the control group. In summary, Shugan Jieyu capsule combined with aerobic exercise can decrease the symptoms of depression and inflammatory response, and promote the efficacy of treatment, sleep quality, and quality of life in patients with depression.