Clinical effects of intrathoracic injection of red Nocardia cell wall skeleton in the treatment of malignant pleural effusion

Abstract

Objective To investigate the effects of intrathoracic injection of red Nocardia cell wall skeleton (N-CWS) in the treatment of malignant pleural effusion. Methods The clinical data of 90 patients with malignant pleural effusion in Longnan Hospital of Daqing from August 2016 to October 2018 were analyzed retrospectively, including 33 cases treated with cisplatin (cisplatin group), 38 cases treated with N-CWS (N-CWS group) and 19 cases treated by chemotherapy combined with N-CWS (combined group). The clinical efficacy and adverse reactions of the three groups were compared. Results The total effective rate of cisplatin group was 48.48%, and the negative rate of pleural effusion cancer cells was 48.48%. The total effective rate of N-CWS group was 84.21%, and the negative rate of pleural effusion cancer cells was 78.94%. The total effective rate of the combined group was 89.47%, and the negative rate of the pleural effusion cancer cells was 84.21%. The total effective rate of the three groups and the negative conversion rate of pleural cancer cells showed a gradual upward trend, and the difference was significant (P<0.05). The main adverse reaction in cisplatin group was gastrointestinal reactions, the main adverse reactions in N-CWS group were fever, chest pain and pleural thickening. Conclusions N-CWS is effective in the treatment of malignant pleural effusions with few adverse reaction. Key words: Malignant pleural effusion; Red Nocardia cell wall skeleton; Intrathoracic injection; Clinical curative effect; Adverse reaction