Abstract
Objective This study is aimed to observe the clinical effects of integrated traditional Chinese and Western medicine in treating severe preeclampsia (SPE) and its effects on maternal and infant outcomes after cesarean section under combined lumbar and epidural anesthesia. Method One hundred and sixty-six pregnant women with SPE were randomly divided into an experimental group and control group, with 83 cases in each group. The control group was given conventional treatments such as magnesium sulfate, and the experimental group received self-made traditional Chinese medicine decoction for oral administration. Results The total clinical effective rate of treatment in the experimental group was significantly higher than that in the control group. After treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and 24 h proteinuria (24 h PRO) levels of the experimental group were significantly lower than those of the control group. After cesarean section (c-section) under combined lumbar and epidural anesthesia, there were statistically significant differences in placental abruption, uterine weakness, fetal intrauterine distress, and neonatal asphyxia in the experimental group, while there were no significant differences in oligohydramnios. After treatment, the contents of inflammatory factors in both groups decreased, and the decrease was more prominent in the experimental group. After treatment, the levels of blood urea nitrogen (BUN), serum creatinine (Scr), and albumin (Alb) and β2 microglobulin (β2-MG) of the two groups of patients decreased, and the levels of them in the experimental group decreased. After treatment, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the two groups increased. However, the levels of malondialdehyde (MDA), lipid peroxide (LPO), and advanced oxidation protein products (AOPP) all reduced, and the increase or decrease in the experimental group was more prominent. Conclusion The combination of traditional Chinese and Western medicine can reduce the blood pressure of a patient with SPE. After the combined spinal-epidural anesthesia and cesarean section, it can significantly improve the maternal and infant outcomes and renal function, reduce inflammatory factors levels and body oxidative stress, and increase the activities of antioxidant enzymes.
Highlights
Severe preeclampsia (SPE) is an idiopathic condition during pregnancy with persistently elevated hypertension and proteinuria (PRO) after 20 weeks of gestation period.Compared with mild-to-moderate preeclampsia, SPE patients often have significantly higher blood pressure and can even have significant symptoms such as persistent headache or upper abdominal pain [1]
Patients in the early stage still need to rely on drug treatment. e spasmolytic and hypotensive methods are often used in clinics, while magnesium sulfate is a common spasmolytic drug, which can dilate smooth muscle and reduce blood vessel resistance and blood pressure in pregnant women [7]
SPE is a common complication of pregnancy-induced hypertension, and its pathogenesis may be related to genetics, diet, immune regulation, and other factors, resulting in elevated blood pressure and inadequate placental perfusion [14]
Summary
Severe preeclampsia (SPE) is an idiopathic condition during pregnancy with persistently elevated hypertension and proteinuria (PRO) after 20 weeks of gestation period. Cesarean sections (c-sections), which can quickly separate the fetus from the adverse intrauterine environment and stop the vicious cycle between mother and fetus, are mainly used for the termination of pregnancy in patients with SPE [4]. Different anesthesia methods used in c-sections for women with SPE have different effects on maternal hemodynamics [5]. Patients in the early stage still need to rely on drug treatment. E spasmolytic and hypotensive methods are often used in clinics, while magnesium sulfate is a common spasmolytic drug, which can dilate smooth muscle and reduce blood vessel resistance and blood pressure in pregnant women [7]. The accumulation of Yin and blood, deficiency of essential qi, imbalance of Yin and Yang of liver and kidney, and disorder of qi and blood result in eclampsia [9]. erefore, one hundred and sixty-six cases of SPE in our hospital were treated with TCM decoction with magnesium sulfate and other conventional treatment, and the outcomes were satisfactory
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