Clinical effects of Cangepingchuanjiaonang in the treatment of non-small cell lung cancer with chronic obstructive pulmonary disease in elderly patients

Abstract

Objective To investigate the clinical effects of cangepingchuanjiaonang in the treatment of non-small cell lung cancer (NSCLC) with Chronic obstructive pulmonary disease (COPD) in elderly patients. Methods 114 elderly patients from Jan 2014 to Jan 2016 with advanced NSCLC with COPD in our hospital were randomly divided observation group and control group. The patients were treated with regular treatment, included oxygen, dilated bronchi and GP chemotherapy. The observation group was given cangepingchuanjiaonang on the base of control group. After treatment, the curative effects were evaluated. Before and after the treatment, the levels of DLCO, FEV1, FEV1/FVC, CD3+ , CD4+ , CD8+ , IgG, IgA and IgM were detected in the two groups. Then the toxicity of the two groups was compared. Results The total effective rate was 84.2% in the observation group, significantly higher than the control group (P<0.05). After the treatment, the levels of DLCO, FEV1, FEV1/FVC, CD3+ , CD4+ , CD8+ , IgG, IgA and IgM were significantly higher in the observation group than which in the control group (P<0.05). During the treatment, there were no serious toxicity in the two groups and the rates of toxicity were significantly lower in the observation group than which in the control group (P<0.05). Conclusion Cangepingchuanjiaonang in the treatment of NSCLC with COPD in elderly patients has a good effect and worth to the next research. Key words: Non-small cell lung cancer; Chronic obstructive pulmonary disease; Cangepingchuanjiaonang