Clinical effects of atopical twin-serum (aqua phase and lipo phase) on skin radiance and wrinkle depth: role of active ingredients and delivery optimisation

Abstract

ntroduction: Skin appearance plays as an important moderator in human daily social interactions so everyday we see new and innovative solutions to fight the signs of aging. One of the important parameters of skin appearance is skin complexion radiance as it could Reflect the general health, emotional State, hormonal status, nutrition, fatigue, age or environmental factors such as smoking, drinking, seasons, etc. Objective: The objective of the study was to evaluate the effect of the daily application of a bi-phasic serum during 8 weeks on the skin radiance and skin aging parameters of healthy women with dull complexion. Subjects and method: 30 healthy female volunteers of 35 to 60 years old were enrolled in the study. The activated product (aquaserum and liposerum) were applied to the face, twice a day for 8 weeks. The evaluation was performed on T0 and T8 weeks by measuring the skin radiance using clinical scoring C.L.B.T.TM and Glossymeter® GL200, Crow’s feet wrinkles by Bazin visual perioral scale, skin elasticity by Cutometer® SM575, and also the subject’s self-assessment. Results: All 30 subjects finished the study without any serious adverse events. The results revealed a significant improvement in all C.L.B.T.TM indicators presenting skin radiance through an increase of Luminosity (29%), Transparency (28%), Brightness (27%) (p=0.001) while a decrease of Pink Red (38%), Olive (31%), Beige (30%), Light Pink (21%) parameters (p<0.001).For skin relief, statistical analyses revealed a significant decrease of wrinkles’ depth evaluated by clinical scoring (9%, p=0.003). For the elasticity, an improvement which tends to be significant (0.462±0.098 at T0 and 0.506±0.111 at T8 weeks; p=0.06) for the Ur/Ue parameter, was observed.After 8 weeks of topical application of Perfectil® Twin-Serum, the subjects significantly found that their skin is less dull (p=0.002), less red (p=0.002), with less spots (p=0.044), less sagging (p=0.002) and less wrinkles (p=0.002). Conclusion: The results observed in this trial show that 8 weeks of Perfectil® Twin Serum use provide beneficial effect on skin radiance and skin surface relief (wrinkle depth). The action of the bi-phasic product may have a positive effect on the immediate penetration of the product which should be evaluated through the further studies. Furthermore, the ingredients seem to restore the skin lipidic layer, which explains its protective effect during winter time.