Clinical Effects of a Phakic Posterior Chamber Implantable Collamer Lens with Centra FLOW for Correcting High Myopia

Abstract

Objective: To study the efficacy, safety, and change in visual quality of a phakic posterior chamber implantable collamer lens with centra FLOW (PPC-ICL V4c) for correcting high myopia. Methods: This was a prospective study of 58 eyes of 32 patients who were candidates for PPC-ICL V4c. The following indicators were compared: preoperative and postoperative uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), preoperative aberrations and aberrations 6 months postoperatively, contrast sensitivity, and the Quality of Life Impact of Refractive Correction (QIRC). All patients were followed up for more than 6 months. Data were analyzed using paired t-tests. Results: Preoperative UCVA (LogMAR visual acuity) and UCVA 6 months after surgery was 1.54±0.26 and -0.04±0.06, respectively. Visual acuity 6 months after surgery improved compared to preoperative acuity (t=30.94, P<0.001). Compared to preoperative BCVA, 56 eyes had equal or better BCVA 6 months after surgery, which accounted for 97% of the total number of eyes. There was an increase of 1 row or better for 28 eyes, which accounted for 48% of the total number of eyes. Postoperative higher-order wavefront aberrations, spherical aberrations, coma, and trefoil root mean square (RMS) were 0.292±0.093 μm, -0.030±0.050 μm, 0.096±0.090 μm, and 0.224±0.091 μm, respectively. Total higher-order aberrations increased and coma was reduced, but the differences were not statistically significant. Spherical aberrations were reduced (t=3.87, P=0.001) and trefoil increased (t=-5.47, P<0.001). All contrast sensitivities 6 months after surgery were better than preoperative levels for 3.0, 6.0, 12.0, and 18.0 cycles/degree. There were also significant differences between the photopic 3.0 and 6.0 cycles/degree and mesopic 6 cycles/degree (t=-2.12, P=0.047; t=-2.51, P=0.021; t=-3.27, P=0.004). The QIRC score for patients improved (t=-2.41, P=0.039) after surgery. Conclusions: Implants of PPC-ICL V4c are a safe and effective surgical method for correcting high myopia. All patients are satisfied with the surgery, which can improve visual quality and quality of life. Key words: phakic intraocular lenses; high myopia; wavefront aberrations; contrast sensitivity; visual quality; quality of life