Abstract
Aims: To determine the effectiveness and safety of sequential computed tomography-guided percutaneous microwave ablation (MWA) after transcatheter arterial chemoembolization(TACE) for hypovascular liver lesions <5cm in size. Methods: The clinical data of 69 hypovascular hepatocellular carcinoma lesions <5cm in 60 patients treated with TACE followed by MWA were retrospectively analyzed. Results: There was no significant difference in AFP levels among AFP-positive patients before and after TACE (p=0.515), but levels were significantly lower 1 month after MWA than before MWA (p=0.039). Compared with 1 month after TACE, the objective response rate (p<0.001) and disease control rate (p=0.004) were increased 1 month after MWA. Any adverse events were well tolerated, and the albumin bilirubin score did not deteriorate within 4 weeks. Conclusion: Sequential MWA after TACE was found to be safe and effective for treating hypovascular hepatocellular carcinoma for lesions <5cm in size.
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